A comparative, in-vivo anti-diabetic study of persimmon peel powder in alloxan induced rabbits

Abstract

Diabetes is a condition when body fails to maintain the glucose levels in the blood properly and the level cross the normal ranges. Natural treatments particularly through bioactive components from fruit and vegetable sources are becoming popular worldwide and are broadly accepted because of no side effects and cost effectiveness. In current study, the antidiabetic potential of persimmon peel powder was investigated by using alloxan induced diabetic rabbits as an animal model. The rabbits were divided into five groups. Persimmon peel powder supplemented diets (0%, 10% and 20%) were given to the diabetic rabbits for the duration of 21 days. The blood samples of rabbits were examined for glucose, serum creatinine and urea levels on weekly basis.  There was a significant decline in the levels of blood glucose in the alloxan induced diabetic rabbits. The reduction of blood glucose level was from 357.66 mg/dL to 256.45 mg/dL when the animals were fed on diet supplemented with 20% persimmon peel powder. Similarly, serum creatinine and urea levels were also significantly reduced because of supplementation of persimmon peel powder. It is concluded from the results that persimmon peel powder might be a potential natural best possible therapeutic option for the management and treatment of Diabetes mellitus.