Mohsen A. Khormi¹, Mohammed A. Alfattah¹, Mabrouk A. Abo-Zaid¹, Saif Elden B. Abdalla², A. El-Shabasy^1*

¹Department of Biology, College of Science, Jazan University, P.O. Box 114, Jazan 45142, Kingdom of Saudi Arabia

²College of Medical Laboratory Science, Jazan University, P.O. Box 114, Jazan 45142, Kingdom of Saudi Arabia

*Corresponding author’s email: ael-shabasy@jazanu.edu.sa

Abstract

The current study is to highlight the effect of natural phyto-product as Moringa oleifera Lam. oil and another artificial insecticide as cypermethrin on efficiency of two different organs of male rats related to different systems; testes and livers. The study utilized probit analysis to determine sub-lethal and lethal doses. Twenty-four male rats were divided into four experimental groups; G1: controlled group, G2 exposed to cypermethrin (CYP), G3 exposed to combination between Moringa oleifera Lam. oil and cypermethrin. G4 treated with moringa oil only. The biochemical analyses were performed as plasma glucose, total protein and albumin levels. ANOVA test besides histological features examined the parenchyma of both studied organs. Cypermethrin had detrimental effects on rats, leading to elevated serum glucose levels, reduced levels of total protein and albumin besides histopathological alterations observed in both studied organs. The molecular docking analysis of a specific testicular protein expressed the high affinity with Cypermethrin active bonds. The findings confirmed on the need of using natural products to overcome the spread of artificial chemicals in our environments.

Keywords: Insecticide, Medicinal plant, Edema, Hemorrhage, Histology, Toxicity, Anticancer